FITC标记的磷脂爬行酶3抗体
产品名称： FITC标记的磷脂爬行酶3抗体
英文名称： Anti-PLSCR3/FITC
产品编号： HZ-7099R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PLSCR3/FITC Conjugated antibody
FITC标记的磷脂爬行酶3抗体
| 英文名称 | Anti-PLSCR3/FITC |
| 中文名称 | FITC标记的磷脂爬行酶3抗体 |
| 别 名 | Ca(2+)-dependent phospholipid scramblase 3; Phospholipid scramblase 3; PL scramblase 3; PLS3; PLS3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PLSCR3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PLSCR3 (phospholipid scramblase 3) may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation. Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. Subunit: Interacts with PDCD6 in a calcium-dependent manner. Subcellular Location: Mitochondrion membrane; Single-pass type II membrane protein. Tissue Specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver. Post-translational modifications: Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity. Similarity: Belongs to the phospholipid scramblase family. Database links: UniProtKB/Swiss-Prot: Q9NRY6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
PLSRC3（磷脂加脂酶3）可介导磷脂结合的钙离子加速磷脂酰亚胺不对称的双向跨膜迁移，导致磷脂膜中磷脂不对称性的丧失。在纤维蛋白凝块形成的启动、肥大细胞的活化和网状内皮系统对凋亡和受损细胞的识别中可能起着中心作用。该家族成员PLS1和PLS3都是蛋白激酶C（PKC）δ的底物，在凋亡过程中被PKCδ磷酸化。PKCδ在凋亡过程中转位到线粒体，磷酸化PLS3。pHS3在HEK293细胞中的过度表达增强了紫外线照射诱导的细胞凋亡。