DPABH-14665 is expected to recognize both reported isoforms (NP_004603.1; NP_001124388.1). The immunizing peptide represents part of a potential extracellular domain.On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. *   http://www.creative-diagnostics.com/Anti-TGFBR1-PAb-194404-147.htm